We successfully characterized and submitted 406 distinct novel MICA alleles, among them 199 novel MICA proteins, to the IPD-IMGT/HLA Database. As a result, we could reduce the number of reported novel MICA alleles during genotyping substantially from 0.3% to 0.03% (German population). Furthermore, MICA allele frequency analyses for the German and South African Black population revealed major differences, including alleles that were almost exclusively found in the South African Black population.